The effects of inhaling 2.5mg of THC is very different from taking 2.5mg orally or sublingually. Yet another factor that can play a major role in influencing the effects is the marijuana delivery method (smoking, vaping, tinctures, edibles, etc.)Īs stated earlier, 2.5mg of THC is a great starting dose for new users, but even that is not so straightforward. This might be related to a concept known as endocannabinoid tone, referring to the unique profile of one’s endocannabinoid system. Everyone has a different tolerance to THC, and it’s not necessarily related to how long one has been consuming cannabis. Tolerance to THCĪnother factor that can play a role is your tolerance to THC. This is an example of the entourage effect theory, according to which the various chemical ingredients in cannabis can interact with one another and influence the user’s experience and therapeutic effects. Interactions with other compoundsįor instance, if CBD is present in your cannabis product (and again, depending on its quantities), you might be able to increase the amount of THC you can tolerate - CBD may counteract some of THC’s side effects, especially THC-induced anxiety. The effectiveness of THC can be influenced by other compounds such as CBD and various terpenes found in the cannabis plant. Russo noted was cancer patients looking to directly treat tumors, where higher doses of THC might be needed. In fact, some studies have suggested that higher doses may be less effective than lower doses to treat pain. Russo, “somewhere between 15-30mg of THC” would be the desired total daily amount.Ĭlinical research suggests that anything more than 30mg a day is likely to increase the side effects of THC, and you probably won’t feel any difference in terms of treating your symptoms. Like with other treatments, you might also be wondering what’s the right frequency (i.e.